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SOPHIA OF WISDOM III - TESTOSTERONE
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THE LIBRARY OF SOPHIA OF WISDOM III
THE SOPHIA OF ALL SOPHIA OF WISDOMS
AKA
CAROLINE E. KENNEDY, JR.____________________
JAN 21, 2007
Testosterone
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Testosterone
Systematic (IUPAC) name
17b-hydroxy-4-androsten-3-one
Identifiers
CAS number 58-22-0
ATC code G03BA03
PubChem 6013
Chemical data
Formula C19H28O2
Mol. weight 288.43
Physical data
Melt. point 155-156 °C (-94 °F)
Spec. rot +110,2°
SEC Combust −11080 kJ/mol
Pharmacokinetic data
Bioavailability ?
Metabolism Liver, Testis and Prostate
Half life 1-12 days
Excretion Urine
Therapeutic considerations
Pregnancy cat. X (USA), Teratogenic effects
Legal status Schedule III (USA)
Schedule IV (Canada)
Routes Intramuscular injection, transdermal (cream, gel, or patch), oral, sub-'Q' pellet
Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females although small amounts are secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty to thirty times the amount of testosterone that an adult female's body does[1].
Contents [hide]
1 Production
2 Effects on humans
2.1 Effects on the brain
3 Mechanism
4 Therapeutic use
4.1 Athletic use
5 Changes during aging
6 References
7 External links
[edit] Production
Like other steroid hormones, testosterone is derived from cholesterol. The largest amounts of testosterone are produced by the testes in men, but it is also synthesized in smaller quantities in women by the thecal cells of the ovaries, by the placenta, as well as by the zona reticularis of the adrenal cortex in both sexes.
In the testes, testosterone is produced by the Leydig cells. The male generative glands also contain Sertoli cells which require testosterone for spermatogenesis. Like most hormones, testosterone is supplied to target tissues in the blood where much of it is transported bound to a specific plasma protein, sex hormone binding globulin (SHBG).
A 2001 study[2] examined the effect of a 3-week period of sexual abstinence followed by masturbation-induced orgasm. It found that abstinence over such periods "does not change the neuroendocrine response to orgasm but does produce elevated levels of testosterone in males."
A 2003 study[3] showed that serum testosterone levels reach a peak seven days after abstaining from ejaculation.
[edit] Effects on humans
In general, androgens promote protein synthesis and growth of those tissues with androgen receptors. Testosterone effects can be classified as virilizing and anabolic effects, although the distinction is somewhat artificial, as many of the effects can be considered both. Anabolic effects include growth of muscle mass and strength, increased bone density and strength, and stimulation of linear growth and bone maturation. Virilizing effects include maturation of the sex organs, particularly the penis and the formation of the scrotum in fetuses, and after birth (usually at puberty) a deepening of the voice, growth of the beard and auxillary hair. Many of these fall into the category of male secondary sex characteristics.
Testosterone effects can also be classified by the age of usual occurrence. For postnatal effects in both males and females, these are mostly dependent on the levels and duration of circulating free testosterone.
Most of the prenatal androgen effects occur between 7 and 12 weeks of gestation.
Genital virilization (midline fusion, phallic urethra, scrotal thinning and rugation, phallic enlargement)
Development of prostate and seminal vesicles
Early infancy androgen effects are the least understood. In the first weeks of life for male infants, testosterone levels rise. The levels remain in a pubertal range for a few months, but usually reach the barely detectable levels of childhood by 4-6 months of age. The function of this rise in humans is unknown. It has been speculated that "brain masculinization" is occurring since no significant changes have been identified in other parts of the body.
Early postnatal effects are the first visible effects of rising androgen levels in childhood, and occur in both boys and girls in puberty.
Adult-type body odour
Increased oiliness of skin and hair, acne
Pubarche (appearance of pubic hair)
Auxillary hair
Growth spurt, accelerated bone maturation
Fine upper lip and sideburn hair
Advanced postnatal effects begin to occur when androgen has been higher than normal adult female levels for months or years. In males these are normal late pubertal effects, and only occur in women after prolonged periods of excessive levels of free testosterone in the blood.
Phallic enlargement (including clitoromegaly)
Increased libido and erection frequency
Pubic hair extends to thighs and up toward umbilicus
Facial hair (sideburns, beard, moustache)
Chest hair, periareolar hair, perianal hair
Subcutaneous fat in face decreases
Increased muscle strength and mass
Deepening of voice
Growth of the adam's apple
Growth of spermatogenic tissue in testes, male fertility
Growth of jaw, brow, chin, nose, and remodeling of facial bone contours
Shoulders widen and rib cage expands
Completion of bone maturation and termination of growth. This occurs indirectly via estradiol metabolites and hence more gradually in men than women.
Adult testosterone effects are more clearly demonstrable in males than in females, but are likely important to both sexes. Some of these effects may decline as testosterone levels decline in the later decades of adult life.
Maintenance of muscle mass and strength
Maintenance of bone density and strength
Libido and erection frequency
Mental and physical energy
[edit] Effects on the brain
As testosterone affects the entire body (often by enlarging; men have bigger hearts, lungs, liver, etc.) the brain is also affected by this "sexual" advancement; the enzyme aromatase converts testosterone into estrogen that is responsible for masculinization of the brain in a male fetus. Factors that in any way reduce aromatase can result in an individual with male gender, male body but with a "female" brain.
There are some differences in a male and female brain (the result of testosterone); a clear difference is the size, the male human brain is on average larger, however in females (that do not use testosterone as much) the corpus callosum is proportionally larger. This means that the effect of testosterone is a greater overall brain volume, but a decreased connection between the hemispheres.[4]
Recent research has suggested that alcohol consumption in women can temporarily raise testosterone levels. A 2006 BBC article states: "According to medical research, testosterone - the hormone connected to male characteristics such as aggression and sex drive - rises in women by up to 50% when they get drunk. In men, it falls" [1]
[edit] Mechanism
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors.
Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5á-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-alpha reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T.[citation needed] The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. It is important to note that if there is a 5-alpha reductase deficiency, the body (of a human) will continue growing into a female with testicles.
Androgen receptors occur in many different vertebrate body system tissues, and both males and females respond similarly to similar levels. Greatly differing amounts of testosterone prenatally, at puberty, and throughout life account for a large share of biological differences between males and females.
The bones and the brain are two important tissues in humans where the primary effect of testosterone is by way of aromatization to estradiol. In the bones, estradiol accelerates maturation of cartilage into bone, leading to closure of the epiphyses and conclusion of growth. In the central nervous system, testosterone is aromatized to estradiol. Estradiol rather than testosterone serves as the most important feedback signal to the hypothalamus (especially affecting LH secretion). In many mammals, prenatal or perinatal "masculinization" of the sexually dimorphic areas of the brain by estradiol derived from testosterone programs later male sexual behavior.
Testosterone is a predominantly male hormone, though females do produce certain amounts of it. The primary female hormone is estrogen and males also produce certain amounts of this hormone. Testosterone causes the appearance of male traits (i.e deepening voice, pubic and facial hairs, muscular build, etc.)
[edit] Therapeutic use
Testosterone was first isolated from a bull in 1935. There have been many pharmaceutical forms over the years. Forms of testosterone for human administration currently available in North America include injectable (such as testosterone cypionate or testosterone enanthate in oil), oral Andriol, buccal Striant, transdermal skin patches, and transdermal creams or gels Androgel and Testim. In the pipeline are "roll on" methods and nasal sprays.
The original and primary use of testosterone is for the treatment of males who have too little or no natural endogenous testosterone production--males with hypogonadism. Appropriate use for this purpose is legitimate hormone replacement therapy, which maintains serum testosterone levels in the normal range.
However, over the years, as with every hormone, testosterone or other anabolic steroids has also been given for many other conditions and purposes besides replacement, with variable success but higher rates of side effects or problems. Examples include infertility, lack of libido or erectile dysfunction, osteoporosis, penile enlargement, height growth, bone marrow stimulation and reversal of anemia, and even appetite stimulation. By the late 1940s testosterone was being touted as an anti-aging wonder drug (e.g., see Paul de Kruif's The Male Hormone). Decline of testosterone production with age has led to a demand for Androgen Replacement Therapy.
To take advantage of its virilizing effects, testosterone is often administered to transmen (female-to-male transsexual people) as part of the hormone replacement therapy, with a "target level" of the normal male testosterone level. Like-wise, transwomen are sometimes prescribed drugs [anti-androgens] to decrease the level of testosterone in the body and allow for the effects of estrogen to develop.
There is a myth that exogenous testosterone can more or less definitively be used for male birth control. However, the vast majority of physicians will agree that to prescribe exogenous testosterone for this purpose is inappropriate. But, perhaps more important, many men found this, in first-hand experience, to be untrue or at least, unreliable. This is especially true when exogenous testosterone is used in conjunction with hCG.[citation needed]
Exogenous testosterone supplementation comes with a number of health risks. Fluoxymesterone and methyltestosterone are synthetic derivatives of testosterone. In 2006 it was reported that women taking Estratest, a combination pill including estrogen and methyltestosterone, were at considerably heightened risk of breast cancer.[citation needed]
Some drugs specifically target testosterone as a way of treating certain conditions. For example, finasteride inhibits the conversion of testosterone into dihydrotestosterone (DHT), a metabolite which is more potent than testosterone. By lowering the levels of dihydrotestosterone, finasteride may be used for various conditions associated with androgens, such as benign prostatic hyperplasia (BPH) and androgenetic alopecia (male-pattern baldness).
[edit] Athletic use
Testosterone may be administered to an athlete in order to improve performance, and is considered to be a form of doping in most sports. There are several application methods for testosterone, including intramuscular injections, transdermal gels and patches, and implantable pellets.
Anabolic steroids (of which testosterone is one) have also been taken to enhance muscle development, strength, or endurance. After a series of scandals and publicity in the 1980s (such as Ben Johnson's improved performance at the 1988 Summer Olympics), prohibitions of anabolic steroid use were renewed or strengthened by many sports organizations. Testosterone and other anabolic steroids were designated a "controlled substance" by the United States Congress in 1990, with the Anabolic Steroid Control Act.[2]
[edit] Changes during aging
Testosterone levels decline gradually with age in men. The clinical significance of this decrease is debated (see andropause). There is disagreement about if and when to treat aging men with testosterone replacement therapy. The American Society of Andrology's position is that testosterone therapy "is indicated when both clinical symptoms and signs suggestive of androgen deficiency and decreased testosterone levels are present". The American Association of Clinical Endocrinologists says "Hypogonadism is defined as a free testosterone level that is below the lower limit of normal for young adult control subjects. Previously, age-related decreases in free testosterone were once accepted as normal. Currently, they are not considered normal....Patients with low-normal to subnormal range testosterone levels warrant a clinical trial of testosterone." [3]
There isn't total agreement on the threshold of testosterone value below which a man would be considered hypogonadal. Testosterone can be measured as "free" (that is, bioavailable and unbound) or
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