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Norwegian Study on Diet, Food Supplements, and MS
Effect of dietary advice and n-3 [omega-3 fatty acid] supplementation in newly diagnosed MS patients
Nordvik, I., Myhr, K.M., Nyland, H., Bjerve, K.S.
Department of Neurology, Haukeland University Hospital, Bergen, Norway
OBJECTIVE: To investigate whether supplementation with fish oil given together with dietary advice and vitamin supplementation influenced the clinical outcome in newly diagnosed multiple sclerosis (MS) patients.
MATERIAL AND METHODS: Sixteen consecutive, newly diagnosed patients with multiple sclerosis were recruited to an open intervention study. They were given dietary advice and supplemented with 0.9 g/day of long-chain marine [omega-3] fatty acids and vitamins. The patients were followed for two years with respect to dietary habits, blood parameters and neurological assessment including exacerbation rate.
RESULTS: There was a significant reduction in the mean annual exacerbation rate and the mean Expanded Disability Status Scale (EDSS) as compared to pre-study values. The plasma total phospholipid n-3 [omega-3] fatty acids increased and n-6 [omega-6] fatty acids decreased significantly.
CONCLUSIONS: The results suggest that fish oil supplementation given together with vitamins and dietary advice can improve clinical outcome in patients with newly diagnosed MS.
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