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Ellagic studies.
REFERENCES
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Ahn D et al. The effects of dietary ellagic acid on rat hepatic and
esophageal mucosal cytochromes P450 and phase II enzymes.
Carcinogenesis 17:821-828, 1996.
Ayrton AD et al. Antimutagenicity of ellagic acid towards the food
mutagen IQ: investigation into possible mechanisms of action. Food
Chem Toxicol 30(4):289-95, 1992.
Barch DH et al. Ellagic Acid Induces NAD(P)H:Quinone Reductase
Through Activation of the Antioxidant Regulatory Element of the Rat
NAD(P)H:Quinone Reductase Gene. Carcinogenesis 15:2065-2068,
1994.
Bhargava UC et al. The mechanism of blood pressure depression by
ellagic acid. Proc Soc Exp Biol Med 132(2):754-6, 1969.
Castonguay A et al. Antitumorigenic and antipromoting activities of
ellagic acid, ellagitannins and oligomeric anthocyanin and
procyanidin. Int J Oncology 10, 367-373, 1997.
Chung, JG Microbios 1998;93(375):115-27
Inhibitory actions of ellagic acid on growth and arylamine Nacetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients.
Department of Medicine, China Medical College, Taiwan, Republic of China.
Arylamine N-acetyltransferase (NAT) activity in Helicobacter pylori
was inhibited by ellagic acid, a possible chemopreventive drug. The
NAT activity was determined using an acetyl CoA recycling assay
and high pressure liquid chromatography. Inhibition of growth
studies using H. pylori demonstrated that ellagic acid elicited a
dose-dependent bactericidal effect in H. pylori cultures, i.e. the
greater the concentration of ellagic acid, the greater the inhibition
of growth of H. pylori. The IC50 value was 1 mM for inhibition of
growth of H. pylori. Cytosols or suspensions of H. pylori with and
without selected concentrations of ellagic acid co-treatment
showed different percentages of 2-aminofluorene and paminobenzoic acid acetylation. The data indicated that there was
decreased NAT activity associated with increased ellagic acid in H.
pylori cytosols and intact cells. For the cytosol and intact bacteria
examinations, the apparent values of K(m) and Vmax decreased
after co-treatment with 1 mM ellagic acid. This report is the first
demonstration of ellagic acid inhibition of arylamine NAT activity
and ellagic acid inhibition of growth in the bacterium H. pylori.
Constantinou A et al. The dietary anticancer agent ellagic acid is a
potent inhibitor of DNA topoisomerases in vitro. Nutr Cancer
23(2):121-30, 1995.
Daniel EM et al. The effects of ellagic acid and 13-cis-retinoic acid
on N- nitrosobenzylmethylamine-induced esophagal tumorigenesis
in rats. Cancer Lett 56:117-124, 1991.
Lesca P. Protective effects of ellagic acid and other plant phenols on
benzo(a)pyrene-induced neoplasia in mice. Carcinogenesis 4:1651-
1653, 1983.
Muktar H et al. Ellagic acid: A potent naturally occurring inhibitor of
benzo[a]pyrene metabolism and its subsequent glucuronidation,
sulfation and covalent binding to DNA in cultured BALA/c mouse
keratinocytes. Carcinogenesis 5: 1565-1571, 1984. Nixon DW.
Alternative and complementary therapies in oncology care. J Clin
Oncol 17(11 Suppl):35-7, 1999. Nixon DW. Prostate cancer and
nutrition. JSC Med Assoc 96(2): 85-6, 2000. Nixon DW. Preventive
medicine in the year 2000. Prev Med 30(1): 1-2, 2000.)
Perchellet JP et al. Antitumor-promoting activities of tannic acid,
ellagic acid, and several gallic acid derivatives in mouse skin. Basic
Life Sci 59:783-801, 1992.
Rao CV et al. Chemoprevention of colon carcinogenesis by dietary
administration of Piroxicam, Difluoromethylornithine, 16beta-
Fluoro-5- androsten-17-one, and Ellagic Acid individually and in
combination. Cancer Research 51: 4528-4534, 1991.
Rommel A et al. Red raspberry phenolic. Influences of processing,
variety and environmental factors. In: Ho C-T, Lee CY, Huan M-T
Eds. Phenolic Compounds in Food and Their Effects on Health I.
Analysis, Occurrence & Chemistry. Washington DC. American
Chemical Society. 259-286, 1992.
Rossi M et al. The crystal and molecular structure of ellagic acid
dihydrate: a dietary anti-cancer agent. Carcinogenesis 12:2227-32,
1991.
Singletary K et al. Ellagic acid effects on the carcinogenicity, DNA binding and metabolism of 7,12-dimethylbenz[a}anthracene
(DMBA). In Vivo 3: 173-176, 1989.
Smart RC et al. Effect of ellagic acid and 3-O-decylellagic acid on
the formation of benzo[a]pyrene-derived DNA adducts in vivo and
on the tumorigenicity of 3-methylcholanthrene in mice.
Carcinogenesis 7(10):1669-75, 1986.
Tanaka T et al. Inhibitory effect of ellagic acid on N-2-
fluoenylacetamide- induced liver carcinogenesis in male AC1/N
rats. Jpn J Cancer Res (Gann) 79:1297-1303, 1988.
Tanaka T et al. Inhibition of 4-nitroquinoline-1-oxide-induced rat
tongue carcinogenesis by the naturally occurring plant phenolics
caffeic, ellagic, chlorogenic and ferulic acids. Carcinogenesis
x14(7):1321-5, 1993.
Teel RW. Ellagic acid binding to DNA as a possible mechanism for
its antimutagenic and anticarcinogenic action. Cancer Lett
30(3):329-36, 1986.
Lesca, P: Protective effects of ellagic acid and other plant phenols on benzo(a)pyrene-induced neoplasia in mice. Carcinogenesis 4:1651-1653, 1983.
Chang, RL, Hùang, MT; Wood, AW; Wong, CQ; Newmark, HL; Yagi H; Sayer, JM; Conney, AH: Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo(a)pyrene and (")-78ß,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene on mouse skin and in the newborn mouse. Carcinogenesis 6:1127-1133, 1985.
Mandal S; Stoner, GD: Inhibition of N-nitrosobenzyl-methylamine-induced esophageal tumorigenesis in rats by ellagic acid. Carcinogenesis 11:55-61, 1990.
Daniel, EM; Stoner, GD: The effects of ellagic acid and 13-cis-retinoic acid on N-nitrosobenzylmethylamine-induced esophagal tumorigenesis in rats. Cancer Lett 56:117-124, 1991.
Siglin, JC; Barch, DH; Stoner, GD: Effects of phenethyl isothiocyanate, ellagic acid, sulindac and supplementary dietary calcium on the induction and progression of esophageal carcinogenesis in rats induced by short-term administration of N-nitrosomethylbenzylamine. Carcinogenesis, 1995.
Tanaka, T; Iwata, H; Niwa, K; Mori, Y; Mori, H: Inhibitory effect of ellagic acid on N-2-fluoenylacetamide-induced liver carcinogenesis in male AC1/N rats. Jpn J Cancer Res (Gann) 79:1297-1303, 1988.
Funt, R.C.; Bash, W.D.; Schwartz, S.J; Collier, J and G. Wenneker. 1997. Small fruit cultivar characteristics for ellagic acid and nutraceutical development. Proceedings Ohio Fruit and Vegetable Growers Congress. pp 110-114.
Stoner, G.D. and Mukhtar, H. Polyphenols as cancer chemopreventative agents. J. Cellular Biochemistry, Supplement 22: 169-180
Protective Effect of Curcumin, Ellagic Acid and Bixin on Radiation Induced Genotoxicity
K.C. Thresiamma, J. George and R. Kuttan Amala Cancer Research Centre, Amala Nagar, Trichur, India
Inhibitory effects of ellagic acid on the direct-acting mutagenicity of aflatoxin B1 in the Salmonella microsuspension assay.
Loarca-Pina G, Kuzmicky PA, de Mejia EG, Kado NY
Departamento de Investigacion y Posgrado, Facultad de Quimica, Universidad Autonoma de Queretaro, Qro., Mexico.
Expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells.
Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW
Cancer Prevention Program, Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, USA.
Regression of atherosclerosis: role of nitric oxide and apoptosis.
Wang BY, Ho HK, Lin PS, Schwarzacher SP, Pollman MJ, Gibbons GH, Tsao PS, Cooke JP
Section of Vascular Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif, USA.
Protective effects of antioxidants on experimental liver injuries.
Suzuki M, Kumazawa N, Ohta S, Kamogawa A, Shinoda M
Faculty of Pharmaceutical Science, Hoshi University, Tokyo, Japan.
Polyphenols as cancer chemopreventive agents.
Stoner GD, Mukhtar H Department of Preventive Medicine, Ohio State University, Columbus 43210, USA.
Ellagic acid induces NAD(P)H:quinone reductase through activation of the antioxidant responsive element of the rat NAD(P)H:quinone reductase gene.
Barch DH, Rundhaugen LM Department of Medicine, Lakeside Veterans Affairs Medical Center, Chicago, IL
Pulmonary carcinogenesis and its prevention by dietary polyphenolic compounds.
Castonguay A Laboratory of Cancer Etiology and Chemoprevention, School of Pharmacy, Laval University, Quebec City, Canada.
Lung tumors in strain A mice: application for studies in cancer chemoprevention.
Stoner GD, Adam-Rodwell G, Morse MA Ohio State University, Department of Preventive Medicine, Arthur G. James Cancer Hospital and Research Institute
*Disclaimer: The above information is for educational purposes
only. It is not intended to diagnose or prescribe. If you have a
medical condtion, we recommend that you see your health care
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